SECONDARY ACUTE LYMPHOBLASTIC-LEUKEMIA WITH T (4-11) - REPORT ON 2 CASES AND REVIEW OF THE LITERATURE

被引：35

作者：

AUXENFANTS, E ^{[1
]}

MOREL, P ^{[1
]}

LAI, JL ^{[1
]}

SARTIAUX, C ^{[1
]}

DETOURMIGNIES, L ^{[1
]}

BAUTERS, F ^{[1
]}

FENAUX, P ^{[1
]}

机构：

[1] CHU LILLE,SERV CYTOGENET,F-59037 LILLE,FRANCE

来源：

ANNALS OF HEMATOLOGY | 1992年 / 65卷 / 03期

关键词：

ACUTE LYMPHOBLASTIC LEUKEMIA; CHROMOSOMAL ABNORMALITIES; SECONDARY LEUKEMIA;

D O I：

10.1007/BF01695815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report two cases of secondary acute lymphoblastic leukemia (ALL) with t (4; 11) (q21; q23) translocation occurring after chemotherapy and radiotherapy for a prior cancer. Seven previously published cases of secondary ALL with t (4; 11) (q21; q23) are also reviewed. Most patients had received a combination of topoisomerase II inhibitors (anthracyclines, mitoxantrone, or the epipodophillotoxin derivatives VP 16 or VM 26) and cyclophosphamide, which have also been implicated in the pathogenesis of secondary acute myeloid leukemia (AML) with 11 q23 rearrangements. These observations give further support to the existence of a subgroup of secondary acute leukemias with cytogenetic findings "specific" for de novo ALL and AML, especially those with translocations involving the 11 q23 region.

引用

页码：143 / 146

页数：4

共 36 条

[1] IMPLICATION OF PRIOR TREATMENT WITH DRUG-COMBINATIONS INCLUDING INHIBITORS OF TOPOISOMERASE-II IN THERAPY-RELATED MONOCYTIC LEUKEMIA WITH A 9-11 TRANSLOCATION [J].