PERIPHERAL ENDOTOXIN INDUCES HYPOTHALAMIC IMMUNOREACTIVE INTERLEUKIN-1-BETA IN THE RAT

被引：68

作者：

HILLHOUSE, EW ^{[1
]}

MOSLEY, K ^{[1
]}

机构：

[1] INST NEUROL,MULTIPLE SCLEROSIS SOC LAB,LONDON WC1N 1PJ,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 109卷 / 02期

关键词：

ENDOTOXIN; INTERLEUKIN-1-BETA; HYPOTHALAMUS;

D O I：

10.1111/j.1476-5381.1993.tb13567.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Interleukin-1 (IL-1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL-1beta in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL-1beta (IL-1beta) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL-1beta.

引用

页码：289 / 290

页数：2

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