EFFECT OF POLICOSANOL ON CEREBRAL-ISCHEMIA IN MONGOLIAN GERBILS - ROLE OF PROSTACYCLIN AND THROMBOXANE A(2)

被引:43
作者
ARRUZAZABALA, ML
MOLINA, V
CARBAJAL, D
VALDES, S
MAS, R
机构
[1] Center of Natural Products, CNIC, Ave 25 and 158, Apdo 6990, Playa, Habana
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 49卷 / 03期
关键词
D O I
10.1016/0952-3278(93)90080-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Policosanol is a mixture of higher primary aliphatic alcohols, isolated from sugar cane wax, whose main component is octacosanol. Policosanol (25, 50 and 200 mg/kg) administered by the oral route not only significantly reduced serum thromboxane B-2 (TXB(2)) levels but also, at 200 mg/kg significantly increased 6-keto-PGF(1 alpha) in Mongolian gerbils. Policosanol at 200 mg/kg significantly protected against cerebral ischemia induced by unilateral ligation of common carotid artery in Mongolian gerbils. In this experimental model, combined administration of ineffective doses of policosanol (25 mg/kg) and aspirin (ASA) (30 mg/kg) significantly protected animals indicating a synergism between them.
引用
收藏
页码:695 / 697
页数:3
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