MOSAIC AND POLYMORPHIC IMPRINTING OF THE WT1 GENE IN HUMANS

被引：168

作者：

JINNO, Y

YUN, KK

NISHIWAKI, K

KUBOTA, T

OGAWA, O

REEVE, AE

NIIKAWA, N

机构：

[1] UNIV OTAGO,SCH MED,DEPT PATHOL,DUNEDIN,NEW ZEALAND

[2] ASAHIKAWA MED COLL,DEPT OBSTET & GYNECOL,ASAHIKAWA 078,JAPAN

[3] UNIV OTAGO,DEPT BIOCHEM,CANC GENET LAB,DUNEDIN,NEW ZEALAND

来源：

NATURE GENETICS | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1038/ng0394-305

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore, because monoallelic expression of WT1 was not found in all placentae examined, WT1 imprinting may be genetically polymorphic within the human population.

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页码：305 / 309

页数：5

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