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IMMUNOREACTIVITY FOR BCL-2 PROTEIN IN MALIGNANT MESOTHELIOMA AND NONNEOPLASTIC MESOTHELIUM

被引：39
作者：
SEGERS, K
RAMAEL, M
KUMAR-SINGH, S
WEYLER, J
VANMEERBEECK, J
VERMEIRE, P
VANMARCK, E
机构：
[1] UNIV HOSP ANTWERP, DEPT PATHOL, B-2650 EDEGEM, BELGIUM
[2] UNIV INSTELLING ANTWERP, DEPT EPIDEMIOL & SOCIAL MED, B-2610 WILRIJK, BELGIUM
[3] UNIV HOSP ANTWERP, DEPT RESP MED, EDEGEM, BELGIUM
来源：
VIRCHOWS ARCHIV | 1994年 / 424卷 / 06期
关键词：
BCL-2; PROTEIN; MESOTHELIOMA; PLEURA; IMMUNOHISTOCHEMISTRY; PROGNOSIS;
D O I：
10.1007/BF01069743
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Immunohistochemical study of bcl-2 protein immunoreactivity in human non-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplasmic immunoreactivity for bcl-2 protein in five cases of malignant mesothelioma. Non-neoplastic mesothelium was not immunoreactive. Immunoreactivity for bcl-2 protein does not add useful prognostic information in malignant mesothelioma since survival times of bcl-2 positive and bcl-2 negative cases did not differ. Nevertheless, the detection of bcl-2 protein in malignant mesothelioma might be useful for the differentiation from reactive mesothelium.
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收藏
页码：631 / 634
页数：4
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