PREDICTION OF RESPONSE TO RADIOTHERAPY IN INVASIVE BLADDER-CANCER

被引：32

作者：

JENKINS, BJ ^{[1
]}

MARTIN, JE ^{[1
]}

BAITHUN, SI ^{[1
]}

ZUK, RJ ^{[1
]}

OLIVER, RTD ^{[1
]}

BLANDY, JP ^{[1
]}

机构：

[1] LONDON HOSP,DEPT UROL,LONDON E1 1BB,ENGLAND

来源：

BRITISH JOURNAL OF UROLOGY | 1990年 / 65卷 / 04期

关键词：

D O I：

10.1111/j.1464-410X.1990.tb14753.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Summary— The original pre‐treatment histological sections from 125 patients with invasive (T2/T3) transitional cell bladder cancer treated by radical radiotherapy were studied; 63 tumours responded completely to radiation and 62 did not; 55 of 72 tumours containing areas of squamous metaplasia and 27 of 36 staining for beta‐human chorionic gonadotrophin failed to respond to radiotherapy; 26 of 28 tumours showing both squamous metaplasia and beta‐human chorionic gonadotrophin did not respond to radiation, whereas 40 of 45 tumours without either of these features responded. The DNA ploidy of 86 tumours in the series was measured by flow cytometry; 11 of 27 aneuploid and 30 of 59 diploid tumours responded to irradiation. Squamous metaplasia and beta‐human chorionic gonadotrophin in bladder cancer indicate resistance to radiotherapy but DNA ploidy does not. © 1990 British Journal of Urology

引用

页码：345 / 348

页数：4

共 13 条

[1] T3 BLADDER-CANCER - THE CASE FOR SALVAGE CYSTECTOMY
BLANDY, JP
ENGLAND, HR
EVANS, SJW
HOPESTONE, HF
MAIR, GMM
MANTELL, BS
OLIVER, RTD
PARIS, AMI
RISDON, RA
[J]. BRITISH JOURNAL OF UROLOGY, 1980, 52 (06): : 506 - 510
[2] RETROSPECTIVE STUDY OF PROGNOSTIC IMPORTANCE OF DNA FLOW-CYTOMETRY OF URINARY-BLADDER CARCINOMA
BLOMJOUS, CEM
SCHIPPER, NW
BAAK, JPA
VANGALEN, EM
DEVOOGT, HJ
MEYER, CJLM
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1988, 41 (01) : 21 - 25
[3] CLINICAL AND BIOLOGICAL SIGNIFICANCE OF ANEUPLOIDY IN HUMAN-TUMORS
FRIEDLANDER, ML
HEDLEY, DW
TAYLOR, IW
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1984, 37 (09) : 961 - 974
[4] BLADDER-CANCER FLOW-CYTOMETRY PROFILES IN RELATION TO HISTOLOGICAL GRADE AND STAGE
HADJISSOTIRIOU, GG
GREEN, DK
SMITH, G
MCINTYRE, MA
HARGREAVE, TB
CHISHOLM, GD
[J]. BRITISH JOURNAL OF UROLOGY, 1987, 60 (03): : 239 - 247
[5] METHOD FOR ANALYSIS OF CELLULAR DNA CONTENT OF PARAFFIN-EMBEDDED PATHOLOGICAL MATERIAL USING FLOW-CYTOMETRY
HEDLEY, DW
FRIEDLANDER, ML
TAYLOR, IW
RUGG, CA
MUSGROVE, EA
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1983, 31 (11) : 1333 - 1335
[6] HOPESTONE HF, 1986, RADIOTHERAPY CLIN PR, P27
[7] REAPPRAISAL OF THE ROLE OF RADICAL RADIOTHERAPY AND SALVAGE CYSTECTOMY IN THE TREATMENT OF INVASIVE (T2/T3) BLADDER-CANCER
JENKINS, BJ
CAULFIELD, MJ
FOWLER, CG
BADENOCH, DF
TIPTAFT, RC
PARIS, AMI
HOPESTONE, HF
OLIVER, RTD
BLANDY, JP
[J]. BRITISH JOURNAL OF UROLOGY, 1988, 62 (04): : 343 - 346
[8] CLINICAL IMPORTANCE OF SQUAMOUS METAPLASIA IN INVASIVE TRANSITIONAL CELL-CARCINOMA OF THE BLADDER
MARTIN, JE
JENKINS, BJ
ZUK, RJ
BLANDY, JP
BAITHUN, SI
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1989, 42 (03) : 250 - 253
[9] HUMAN CHORIONIC-GONADOTROPIN EXPRESSION AND HISTOLOGICAL-FINDINGS AS PREDICTORS OF RESPONSE TO RADIOTHERAPY IN CARCINOMA OF THE BLADDER
MARTIN, JE
JENKINS, BJ
ZUK, RJ
OLIVER, RTD
BAITHUN, SI
[J]. VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1989, 414 (03) : 273 - 277
[10] RODENBURG CJ, 1985, ARCH PATHOL LAB MED, V109, P1046

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