8-BROMO-6-ALKYLAMINO-2-TRIFLUOROMETHYL-9H-PURINES WITH INVITRO ACTIVITY AGAINST INFLUENZA A-VIRUS

被引：4

作者：

KELLEY, JL ^{[1
]}

LINN, JA ^{[1
]}

TISDALE, M ^{[1
]}

机构：

[1] WELLCOME RES LABS, BECKENHAM BR3 3BS, KENT, ENGLAND

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 05期

关键词：

D O I：

10.1002/jhet.5570270560

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several derivatives of 8‐bromo‐6‐dimethylamino‐2‐trifluoromethyl‐9H‐purine (1) were synthesized for structure‐activity relationship studies of anti‐influenza A virus activity. The 8‐bromopurines were prepared by reaction of the anion of the 6‐alkylamino‐2‐trifluoromethylpurines with N‐bromosuccinimide. Several compounds had anti‐influenza activity comparable to ribavirin, but no in vivo activity was observed. Copyright © 1990 Journal of Heterocyclic Chemistry

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页码：1505 / 1508

页数：4

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