EFFECTS OF HARMANE (1-METHYL-BETA-CARBOLINE) ON NEURONS IN THE NUCLEUS-ACCUMBENS OF THE RAT

被引:38
作者
ERGENE, E
SCHOENER, EP
机构
[1] WAYNE STATE UNIV, SCH MED, DEPT PHARMACOL, 540 E CANFIELD, DETROIT, MI 48201 USA
[2] WAYNE STATE UNIV, SCH MED, DEPT PHYSIOL, DETROIT, MI 48201 USA
关键词
HARMANE; NUCLEUS ACCUMBENS; BETA-CARBOLINES; REWARD SYSTEM; ALCOHOLISM;
D O I
10.1016/0091-3057(93)90030-W
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Harmane, a beta-carboline alkaloid reported to exert locomotor and psychoactive effects, is found in certain plants and also has been shown to exist in the mammalian brain as an endogenous substance. In this study, the effects of locally perfused harmane were examined on spontaneous neuronal activity in the nucleus accumbens of urethane-anesthetized rats. Extracellular single-unit recording, coupled with push-pull perfusion, enabled the discrimination of specific, dose-related effects of harmane across a wide concentration range. At lower concentrations (10(-9)-10(-11) M), excitation prevailed, while at higher concentrations (10(-8)-10(-6) M) depression was most pronounced. These findings suggest a neuromodulatory role for harmane in the forebrain reward system.
引用
收藏
页码:951 / 957
页数:7
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