EFFECTS OF COCAINE ON P3B IN COCAINE ABUSERS

被引：10

作者：

HERNING, RI

GLOVER, BJ

GUO, XY

机构：

[1] Molecular Neuropsychiatry Section, National Institutes of Health, National Institute on Drug Abuse, Baltimore, MD

来源：

NEUROPSYCHOBIOLOGY | 1994年 / 30卷 / 2-3期

关键词：

COCAINE; INFORMATION PROCESSING; P300; P3B; SLOW WAVE;

D O I：

10.1159/000119148

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significantly larger 60-210 min after the cocaine than after the placebo injection. The results suggest that cocaine abusers have difficulty in maintaining optimal stimulus processing during extended testing. Cocaine blocks this decrement in stimulus processing.

引用

页码：132 / 142

页数：11

共 34 条

[1] DOES METHYLPHENIDATE AFFECT INFORMATION-PROCESSING - FINDINGS FROM 2 STUDIES ON PERFORMANCE AND P3B LATENCY [J].

BRUMAGHIM, JT ;

KLORMAN, R ;

STRAUSS, J ;

LEWINE, JD ;

GOLDSTEIN, MG .

PSYCHOPHYSIOLOGY, 1987, 24 (03) :361-373

[2]

CALLAWAY E, 1984, BIOL PSYCHIAT, V19, P649

[3] EFFECT OF METHYLPHENIDATE ON YOUNG-ADULTS VIGILANCE AND EVENT-RELATED POTENTIALS [J].

COONS, HW ;

PELOQUIN, LJ ;

KLORMAN, R ;

BAUER, LO ;

RYAN, RM ;

PERLMUTTER, RA ;

SALZMAN, LF .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1981, 51 (04) :373-387

[4] P300 AND INTROVERTED EXTRAVERTED PERSONALITY-TYPES [J].

DITRAGLIA, GM ;

POLICH, J .

PSYCHOPHYSIOLOGY, 1991, 28 (02) :177-184

[5]

DONCHIN E, 1988, BEHAV BRAIN SCI, V38, P387

[6] COCAINE EFFECTS IN SLEEP-DEPRIVED HUMANS [J].

FISCHMAN, MW ;

SCHUSTER, CR .

PSYCHOPHARMACOLOGY, 1980, 72 (01) :1-8

[7]

FITZPATRICKK P, 1990, PSYCHOPHYSIOLOGY, V25, P292

[8] THE EFFECTS OF COMBINATIONS OF INTRANASAL COCAINE, SMOKED MARIJUANA, AND TASK-PERFORMANCE ON HEART-RATE AND BLOOD-PRESSURE [J].

FOLTIN, RW ;

FISCHMAN, MW .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 36 (02) :311-315

[9]

FREUD S, 1974, COCAINE PAPERS

[10] SELECTIVE EFFECTS OF BARBITURATE AND AMPHETAMINE ON INFORMATION-PROCESSING AND RESPONSE EXECUTION [J].

FROWEIN, HW .

ACTA PSYCHOLOGICA, 1981, 47 (02) :105-115

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