Noradrenergic modulation of central serotonergic neurotransmission: Acute and long-term actions of mirtazapine

被引:68
作者
Haddjeri, N
Blier, P
deMontigny, C
机构
[1] Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montréal, QC, H3A 1A1
关键词
adrenoceptors; noradrenaline; modulation; serotonin neurotransmission; mirtazapine; antidepressant;
D O I
10.1097/00004850-199512004-00003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Mirtazapine (Org3770, Remeron) is a new alpha(2)-adrenoceptor antagonist which is an effective antidepressant drug. An in vivo electrophysiological paradigm in the rat was used to assess the effects of acute and long-term treatment with mirtazapine on pre- and postsynaptic alpha(2)-adrenoceptors and to determine whether this drug can modulate serotonin (5-HT) neurotransmission. The acute administration of mirtazapine produced a rapid increase in both noradrenaline and 5-HT neurotransmission by blocking both alpha(2)-adrenergic auto- and heteroreceptors, resulting in an enhanced tonic activation of postsynaptic 5-HT receptors. Long-term administration showed that this tonic activation of postsynaptic 5-HT receptors was most likely enhanced after such a treatment as a result of a sustained increase in 5-HT neuronal activity in the presence of and due to inactivated alpha(2)-adrenergic heteroreceptors.
引用
收藏
页码:11 / 17
页数:7
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