RECEPTOR-G PROTEIN COUPLING IS ESTABLISHED BY A POTENTIAL CONFORMATIONAL SWITCH IN THE BETA-GAMMA COMPLEX

被引：94

作者：

KISSELEV, O

PRONIN, A

ERMOLAEVA, M

GAUTAM, N

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANESTHESIOL,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 20期

关键词：

D O I：

10.1073/pnas.92.20.9102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Receptor-G protein interaction is characterized by cycles of association and dissociation. We present evidence which indicates that during receptor-G protein interaction, the C-terminal tail of the G protein gamma subunit, which is masked in the beta gamma complex, is exposed and establishes high-affinity contact with the receptor. This potential conformational switch provides a mechanism to regulate receptor-G protein coupling. This switch may also be significant for the role of the beta gamma complex in regulation of effector function.

引用

页码：9102 / 9106

页数：5

共 40 条

[1]

BENNETT N, 1985, J BIOL CHEM, V260, P4156

[2] LIGHT-INDUCED INTERACTION BETWEEN RHODOPSIN AND THE GTP-BINDING PROTEIN METARHODOPSIN-II IS THE MAJOR PHOTOPRODUCT INVOLVED [J].