EFFECTS OF ZINC L-CARNOSINE ON GASTRIC-MUCOSAL AND CELL-DAMAGE CAUSED BY ETHANOL IN RATS - CORRELATION WITH ENDOGENOUS PROSTAGLANDIN-E2

被引：57

作者：

ARAKAWA, T ^{[1
]}

SATOH, H ^{[1
]}

NAKAMURA, A ^{[1
]}

NEBIKI, H ^{[1
]}

FUKUDA, T ^{[1
]}

SAKUMA, H ^{[1
]}

NAKAMURA, H ^{[1
]}

ISHIKAWA, M ^{[1
]}

SEIKI, M ^{[1
]}

KOBAYASHI, K ^{[1
]}

机构：

[1] ZERIA PHARMACEUT CO LTD,CENT RES LABS,DEPT BIOL SCI,SAITAMA 36001,JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1990年 / 35卷 / 05期

关键词：

cytoprotection; gastric mucosa; indomethacin; prostaglandin; zinc; zinc l-carnosine;

D O I：

10.1007/BF01540402

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effects of zinc l-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosa in vivo and in vivo. When given either intragastrically or intraperitoneally, zinc l-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zinc l-carnosine was not inhibited by indomethacin. Histological assessment showed that zinc l-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl-prostaglandin E2. Zinc l-carnosine (10-6 or 10-5 M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosa in vivo; this effect was not inhibited by indomethacin. The results suggested that zinc l-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins. © 1990 Plenum Publishing Corporation.

引用

页码：559 / 566

页数：8

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