DIRECTED METALATION OF PYRIDINESULPHONAMIDES - SYNTHESIS OF PYRIDINE-FUSED ISOTHIAZOLES AND 1,2-OXATHIOLES

被引：13

作者：

ALO, BI ^{[1
]}

FAMILONI, OB ^{[1
]}

MARSAIS, F ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INST NATL SCI APPL,LIRCOF,CHIM ORGAN HETEROCYCL LAB,F-76130 MONT ST AIGNAN,FRANCE

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 01期

关键词：

D O I：

10.1002/jhet.5570290109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Lithio-N-t-butylpyridine-3-sulphonamide reacted with benzophenone and carbon dioxide respectively to give the corresponding intermediates which on appropriate treatment gave isothiazolo[5,4-c]pyridin-3-one 1,1-dioxides. Metalation of 2- and 4-(N,N-dialkylaminosulphonyl)pyridines with lithium diisopropylamide (LDA) gave anions which reacted with benzophenone to give carbinols which thermally cyclised to 1,2-oxathiolo[3,4-b]pyridine and 1,2-oxathiolo[4,3-c]pyridine respectively.

引用

页码：61 / 64

页数：4

共 16 条

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