SKELETAL CHANGES IN THE OVARIECTOMIZED EWE AND SUBSEQUENT RESPONSE TO TREATMENT WITH 17-BETA ESTRADIOL

被引：30

作者：

HORNBY, SB ^{[1
]}

FORD, SL ^{[1
]}

MASE, CA ^{[1
]}

EVANS, GP ^{[1
]}

机构：

[1] BAYER INC,W HAVEN,CT 06516

来源：

BONE | 1995年 / 17卷 / 04期

关键词：

D O I：

10.1016/8756-3282(95)00316-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ewe has been suggested as a suitable large animal model for assessment of therapeutic agents for the treatment of osteoporosis. In this study we asses the response of ewe bone;mineral parameters, using dual energy x ray absorptiometry (DXA), after ovariectomy. Regular DXA analysis was performed over a period of 75 weeks followed by a period of dosing with 17 beta oestradiol. Total body bone mineral density (BMD) was reduced in ovariectomised animals 15 weeks post operatively. BMD remained lower than control animals for the entire pre dose period. Subsequently, dosing with 17 beta oestradiol prevented further loss of bone over a period of 38 weeks. Several complicating factors were noted during the study including seasonal BMD variation, a correlation between fat/lean ratio and total body BMD together with a reversible reduction in bone mineral content as a result of lactation. Also changes in BMD were associated with age at ovariectomy.

引用

页码：S389 / S394

页数：6

共 10 条

[1] REVIEWS OF PROGRESS OF DAIRY SCIENCE - CALCIUM AND PHOSPHORUS-METABOLISM IN RUMINANTS WITH SPECIAL REFERENCE TO PARTURIENT PARESIS [J].