INHIBITION OF GASTRIC H+,K+-ATPASE BY CHALCONE DERIVATIVES, XANTHOANGELOL AND 4-HYDROXYDERRICIN, FROM ANGELICA-KEISKEI KOIDZUMI

被引：46

作者：

MURAKAMI, S ^{[1
]}

KIJIMA, H ^{[1
]}

ISOBE, Y ^{[1
]}

MURAMATSU, M ^{[1
]}

AIHARA, H ^{[1
]}

OTOMO, S ^{[1
]}

BABA, K ^{[1
]}

KOZAWA, M ^{[1
]}

机构：

[1] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb06568.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Two chalcone derivatives, xanthoangelol (I) and 4‐hydroxyderricin (II) isolated from Angelica keiskei Koidzumi, inhibited pig gastric H+, K+ ‐ATPase with IC50 values of 1.8 and 3.3 μM, respectively. The inhibition by I or II was competitive with respect to ATP and was non‐competitive with respect to K+. I and II also inhibited K+, stimulated p‐nitrophenyl phosphatase, with IC50 values of 1.3 and 3.5 μM, respectively. Proton transport in‐vitro was inhibited by I or II, in a dose‐dependent manner. I at 100 mg kg−1, i.p. significantly inhibited acid secretion and the formation of stress‐induced gastric lesions. These results suggest that the antisecretory effect of I is due to the inhibition of gastric H+, K+‐ATPase. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：723 / 726

页数：4

共 13 条

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