TESTING FOR FLUOXYMESTERONE (HALOTESTIN) ADMINISTRATION TO MAN - IDENTIFICATION OF URINARY METABOLITES BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：11

作者：

KAMMERER, RC ^{[1
]}

MERDINK, JL ^{[1
]}

JAGELS, M ^{[1
]}

CATLIN, DH ^{[1
]}

HUI, KK ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,PAUL ZIFFREN OLYMP ANALYT LAB,LOS ANGELES,CA 90024

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 36卷 / 06期

关键词：

D O I：

10.1016/0022-4731(90)90185-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluoxymesterone, an anabolic steroid, is metabolized in man primarily by 6β-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. These pathways of metabolism are suggested by the positive identification of 4 metabolites and the tentative identification of 3 other metabolites. Detection of the drug in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males, by monitoring the presence of 2 metabolites, since the parent drug is not detectable more than 1 day after the dose. © 1990.

引用

页码：659 / 666

页数：8

共 37 条

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