NUCLEOTIDE-SEQUENCE OF THE YERSINIA-PESTIS GENE ENCODING F1 ANTIGEN AND THE PRIMARY STRUCTURE OF THE PROTEIN - PUTATIVE T-CELL AND B-CELL EPITOPES

被引：95

作者：

GALYOV, EE

SMIRNOV, OY

KARLISHEV, AV

VOLKOVOY, KI

DENESYUK, AJ

NAZIMOV, IV

RUBTSOV, KS

ABRAMOV, VM

DALVADYANZ, SM

ZAVYALOV, VP

机构：

[1] MINIST MED IND USSR,INST IMMUNOL,142380 LYUBUCHANY,USSR

[2] MINIST MED IND USSR,ALL UNION RES INST APPL MICROBIOL,142279 OBOLENSK,USSR

[3] MM SHEMYAKIN BIOORGAN CHEM INST,MOSCOW 117312,USSR

[4] MINIST HLTH USSR,ALL UNION ANTIPLAGUE INST MICROB,410071 SARATOV,USSR

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

CAPSULAR ANTIGEN; NUCLEOTIDE SEQUENCE; SIGNAL SEQUENCE; ANTIGENIC DETERMINANT; YERSINIA-PESTIS;

D O I：

10.1016/0014-5793(90)80852-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plasmid-located gene cafl encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced M(r) of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli consensus signal sequence. The F1 was assumed to have beta-sheet structure for the most part. The region located between amino acids 100 and 150 was suggested to contain putative antigenic determinants and to stimulate T cells.

引用

页码：230 / 232

页数：3

共 16 条

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