IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN LEIOMYOMAS FROM WOMEN TREATED WITH GOSERELIN DEPOT

被引：12

作者：

LEONE, M

CUCUCCIO, S

VENTURINI, PL

MENADA, MV

LEONE, MM

DECECCO, L

机构：

[1] UNIV GENOA,DEPT OBSTET & GYNECOL,I-16126 GENOA,ITALY

[2] UNIV GENOA,DEPT HISTOL & EMBRYOL,I-16126 GENOA,ITALY

来源：

HORMONE AND METABOLIC RESEARCH | 1991年 / 23卷 / 09期

关键词：

FIBROIDS; EGF; ANGIOGENESIS; GNRH AGONIST;

D O I：

10.1055/s-2007-1003722

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocytes. In fibroids from treated patients the histochemical score (HSCORE) of vessel cells was always significantly lower (p < 0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

引用

页码：442 / 445

页数：4

共 10 条

[1]

CARPENTER G, 1987, ANNU REV BIOCHEM, V56, P881, DOI 10.1146/annurev.bi.56.070187.004313

[2]

FAYED YM, 1989, LAB INVEST, V60, P30

[3] CONTROL OF PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELLS - CHARACTERIZATION OF RESPONSE OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS TO FIBROBLAST GROWTH-FACTOR, EPIDERMAL GROWTH-FACTOR, AND THROMBIN [J].