CALCIUM-ANTAGONISTIC EFFECTS OF CARBAMAZEPINE IN EPILEPSIES AND AFFECTIVE PSYCHOSES

被引:33
作者
WALDEN, J
GRUNZE, H
MAYER, A
DUSING, R
SCHIRRMACHER, K
LIU, Z
BINGMANN, D
机构
[1] UNIV FREIBURG,PSYCHIAT KLIN,W-7800 FREIBURG,GERMANY
[2] DESITIN ARZNEIMITTEL GMBH,HAMBURG,GERMANY
[3] UNIV ESSEN GESAMTHSCH,INST PHYSIOL,W-4300 ESSEN 1,GERMANY
关键词
PAROXYSMAL DEPOLARIZATIONS; CA3; NEURONS; CARBAMAZEPINE; CALCIUM ANTAGONISTS; CAFFEINE; PENICILLIN; LOW MG2+;
D O I
10.1159/000118975
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Carbamazepine (CBZ) is known to have beneficial effects in the treatment of epilepsies and in the prophylaxis of affective disorders. Since increased transmembrane calcium fluxes and intracellular calcium concentrations play a key role in the generation of epilepsies and possibly also in the development of these psychiatric disorders the effects of CBZ on epileptic discharges (elicited by caffeine, penicillin and low Mg2+) in CA3 neurons of hippocampal slices were compared with those of the organic calcium antagonist verapamil and found to be almost the same.
引用
收藏
页码:171 / 175
页数:5
相关论文
共 19 条
[1]  
BINGMANN D, 1989, EXP BRAIN RES, V74, P239
[2]  
BINGMANN D, 1973, EPILEPSY MOTOR SYSTE, P139
[3]  
CATTERALL WA, 1992, PHYSIOL REV, V72, pS5
[4]   GAMMA-AMINOBUTYRIC ACID-INDUCED DEPRESSION OF CALCIUM CURRENTS OF CHICK SENSORY NEURONS [J].
DEISZ, RA ;
LUX, HD .
NEUROSCIENCE LETTERS, 1985, 56 (02) :205-210
[5]  
DUBOVSKY SL, 1983, BIOL PSYCHIAT, V18, P781
[6]   VERAPAMIL IN AFFECTIVE-DISORDERS - A CONTROLLED, DOUBLE-BLIND-STUDY [J].
HOSCHL, C ;
KOZENY, J .
BIOLOGICAL PSYCHIATRY, 1989, 25 (02) :128-140
[7]   EFFECT OF IMIPRAMINE ON CALCIUM AND POTASSIUM CURRENTS IN ISOLATED BOVINE VENTRICULAR MYOCYTES [J].
ISENBERG, G ;
TAMARGO, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 108 (02) :121-131
[8]   MULTIPLE CALCIUM CHANNELS AND NEURONAL FUNCTION [J].
MILLER, RJ .
SCIENCE, 1987, 235 (4784) :46-52
[9]   LOW EXTRACELLULAR MAGNESIUM INDUCES EPILEPTIFORM ACTIVITY AND SPREADING DEPRESSION IN RAT HIPPOCAMPAL SLICES [J].
MODY, I ;
LAMBERT, JDC ;
HEINEMANN, U .
JOURNAL OF NEUROPHYSIOLOGY, 1987, 57 (03) :869-888
[10]   CAFFEINE-INDUCED EPILEPTIC DISCHARGES IN CA3 NEURONS OF HIPPOCAMPAL SLICES OF THE GUINEA-PIG [J].
MORAIDIS, I ;
BINGMANN, D ;
LEHMENKUHLER, A ;
SPECKMANN, EJ .
NEUROSCIENCE LETTERS, 1991, 129 (01) :51-54