L-696,474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE .2. ISOLATION AND STRUCTURE

被引：44

作者：

ONDEYKA, J

HENSENS, OD

ZINK, D

BALL, R

LINGHAM, RB

BILLS, G

DOMBROWSKI, A

GOETZ, M

机构：

[1] MERCK SHARP & DOHME LTD, DEPT BIOPHYS CHEM, RAHWAY, NJ 07065 USA

[2] MERCK SHARP & DOHME LTD, DEPT BASIC MICROBIOL, RAHWAY, NJ 07065 USA

[3] MERCK SHARP & DOHME LTD, DEPT MICROBIAL CHEMOTHERAPEUT & MOLEC GENET, RAHWAY, NJ 07065 USA

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 05期

关键词：

D O I：

10.7164/antibiotics.45.679

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel HIV-1 protease inhibitor, L-696,474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696.474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.

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页码：679 / 685

页数：7

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