BRADYKININ ELEVATES TYROSINE-HYDROXYLASE AND DOPAMINE BETA-HYDROXYLASE MESSENGER-RNA LEVELS IN PC12 CELLS

被引：14

作者：

GEBREYESUS, K ^{[1
]}

KILBOURNE, EJ ^{[1
]}

SABBAN, EL ^{[1
]}

机构：

[1] NEW YORK MED COLL,DEPT BIOCHEM & MOLEC BIOL,VALHALLA,NY 10595

来源：

BRAIN RESEARCH | 1993年 / 608卷 / 02期

关键词：

BRADYKININ; TYROSINE HYDROXYLASE; DOPAMINE BETA-HYDROXYLASE; CALCIUM; MESSENGER RNA; CATECHOLAMINE;

D O I：

10.1016/0006-8993(93)91477-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 muM bradykinin for 3 h markedly elevated both TH and dopamine beta-hydroxylase (DBH) mRNA levels.

引用

页码：345 / 348

页数：4

共 32 条

[1] NEUROTRANSMITTER RELEASE FROM BRADYKININ-STIMULATED PC12 CELLS - STIMULATION OF CYTOSOLIC CALCIUM AND NEUROTRANSMITTER RELEASE [J].

APPELL, KC ;

BAREFOOT, DS .

BIOCHEMICAL JOURNAL, 1989, 263 (01) :11-18

[2] STRESS HORMONES - THEIR INTERACTION AND REGULATION [J].

AXELROD, J ;

REISINE, TD .

SCIENCE, 1984, 224 (4648) :452-459

[3] THE DIFFERENTIAL-EFFECTS OF CELL-DENSITY AND NGF ON THE EXPRESSION OF TYROSINE-HYDROXYLASE AND DOPAMINE BETA-HYDROXYLASE IN PC12 CELLS [J].

BADOYANNIS, HC ;

SHARMA, SC ;

SABBAN, EL .

MOLECULAR BRAIN RESEARCH, 1991, 11 (01) :79-87

[4] PREGANGLIONIC NERVE-STIMULATION INCREASES MESSENGER-RNA LEVELS FOR TYROSINE-HYDROXYLASE IN THE RAT SUPERIOR CERVICAL-GANGLION [J].

BIGUET, NF ;

RITTENHOUSE, AR ;

MALLET, J ;

ZIGMOND, RE .

NEUROSCIENCE LETTERS, 1989, 104 (1-2) :189-194

[5]

CHALAZONITIS A, 1980, J PHARMACOL EXP THER, V213, P139

[6]

CHAN YL, 1984, J BIOL CHEM, V259, P224

[7]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[8] P1B15 - A CDNA CLONE OF THE RAT MESSENGER-RNA ENCODING CYCLOPHILIN [J].

DANIELSON, PE ;

FORSSPETTER, S ;

BROW, MA ;

CALAVETTA, L ;

DOUGLASS, J ;

MILNER, RJ ;

SUTCLIFFE, JG .

DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1988, 7 (04) :261-267

[9]

DAS B, 1992, J NEUROCHEM, V59, P2263

[10]

FASOLATO C, 1988, J BIOL CHEM, V263, P17350

← 1 2 3 4 →