COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY - EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR

被引：30

作者：

SELMAN, SH

HAMPTON, JA

MORGAN, AR

KECK, RW

BALKANY, AD

SKALKOS, D

机构：

[1] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699

[2] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43699

[3] UNIV TOLEDO,DEPT MED CHEM,TOLEDO,OH 43699

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1993年 / 57卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1993.tb02937.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An iminium salt of octaethylbenzochlorin with copper in the aromatic ring, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to be an effective photosensitizer in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin photosensitization was found to be minimal when drug-injected mice were illuminated in a solar simulator.

引用

页码：681 / 685

页数：5

共 11 条

[1]

Doiron D R, 1986, Curr Probl Dermatol, V15, P85

[2] STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN-II [J].