SAFETY AND OPTIMUM CONCENTRATION OF A MANGANESE CHLORIDE-BASED ORAL MR CONTRAST AGENT

被引:30
作者
BERNARDINO, ME
WEINREB, JC
MITCHELL, DG
SMALL, WC
MORRIS, M
机构
[1] NYU, MED CTR, DEPT RADIOL, NEW YORK, NY USA
[2] THOMAS JEFFERSON UNIV HOSP, DEPT RADIOL, PHILADELPHIA, PA USA
[3] SQUIBB DIAGNOST, PLAINSBORO, NJ USA
关键词
CONTRAST ENHANCEMENT; CONTRAST MEDIA; INTESTINES; MR; MANGANESE; STOMACH;
D O I
10.1002/jmri.1880040620
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To determine the safety of a manganese chloride-based oral magnetic resonance (MR) contrast agent and the ideal concentration of the agent for marking in three different anatomic sites (stomach, middle of the small bowel, and ileocecal region), six healthy volunteers were evaluated before and after administration of 900 mL of three different concentrations of the contrast agent. Images were evaluated subjectively and objectively. No adverse events were noted. There was a minimal rise in manganese blood levels at 6 hours after administration, with a return to baseline at 24 hours. The imaging data demonstrated good-to-excellent bowel marking on T1-weighted images at all three concentrations. However, on T2-weighted images, the 40 mg Mn+2/L concentration provided improved hypointense bowel marking relative to the 20 mg/L concentration. Little difference was seen between the 40 and 60 mg/L concentrations. Fast T1- and Ta-weighted sequences provided superior image quality to that of conventional spin-echo sequences.
引用
收藏
页码:872 / 876
页数:5
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