A BEHAVIORALLY ACTIVE DOSE OF LIPOPOLYSACCHARIDE INCREASES SENSORY NEUROPEPTIDES LEVELS IN MOUSE SPINAL-CORD

被引：24

作者：

BRETDIBAT, JL

KENT, S

COURAUD, JY

CREMINON, C

DANTZER, R

机构：

[1] INSERM, U394, F-33077 BORDEAUX, FRANCE

[2] CEA SACLAY, DSV, DRIPP, ETUD RADIO IMMUNOL LAB, F-91191 GIF SUR YVETTE, FRANCE

[3] UNIV PARIS 07, UFR BIOL, PARIS, FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

LIPOPOLYSACCHARIDE; INDOMETHACIN; OPERANT BEHAVIOR; SPINAL CORD; MOUSE; FEEDING; SUBSTANCE P; CALCITONIN GENE-RELATED PEPTIDE;

D O I：

10.1016/0304-3940(94)90184-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To assess whether peripheral immune stimuli activate sensory afferents at behaviorally active doses, we measured the effects of lipopolysaccharide (LPS) on the levels of sensory neuropeptides in the spinal cord. LPS (10 mu g/mouse i.p.) increased the levels of substance P, neurokinin A, and calcitonin gene-related peptide in the spinal cord, the maximum being observed 1 hr post-injection. Pretreatment with indomethacin at a dose (5 mg/kg i.p.) which completely blocked the decrease in food-motivated behavior induced by LPS abrogated this effect.

引用

页码：205 / 209

页数：5

共 28 条

[1] EFFECT OF BRADYKININ AND PROSTAGLANDINS ON THE RELEASE OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY FROM THE RAT SPINAL-CORD INVITRO [J].