BASIC FIBROBLAST GROWTH-FACTOR INCREASES DOPAMINERGIC GRAFT-SURVIVAL AND FUNCTION IN A RAT MODEL OF PARKINSONS-DISEASE

被引:180
作者
TAKAYAMA, H
RAY, J
RAYMON, HK
BAIRD, A
HOGG, J
FISHER, LJ
GAGE, FH
机构
[1] UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
[2] WHITTIER INST DIABET & ENDOCRINOL, LA JOLLA, CA 92037 USA
关键词
D O I
10.1038/nm0195-53
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The clinical use of fetal neural grafts as an intracerebral source of dopamine for patients with Parkinson's disease has, met with limited success. Since basic fibroblast growth factor (bFGF) enhances the survival and growth of dopaminergic neurons in vitro, we explored whether cells genetically modified to produce bFGF would improve the functional efficacy of dopaminergic neurons implanted into rats with experimental Parkinson's disease. Results show that bFGF-producing cells grafted together with fetal dopamine neurons have potent growth-promoting effects on the implanted neurons in vivo. Moreover, rats implanted with such co-grafts display the most pronounced behavioural improvements post-grafting. These findings not only provide insight into the function of bFGF in situ, but also suggest an approach for enhancing the survival and function of dopamine neurons grafted into the damaged brain.
引用
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页码:53 / 58
页数:6
相关论文
共 31 条
[1]   ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].
ABERCROMBIE, M .
ANATOMICAL RECORD, 1946, 94 (02) :239-247
[2]   CEREBRAL TRANSPLANTATION FOR PARKINSONS-DISEASE - CURRENT PROGRESS AND FUTURE-PROSPECTS [J].
AHLSKOG, JE .
MAYO CLINIC PROCEEDINGS, 1993, 68 (06) :578-591
[4]  
Baird A., 1991, PEPTIDE GROWTH FACTO, V1, P369
[5]   RECONSTRUCTION OF THE NIGROSTRIATAL DOPAMINE PATHWAY BY INTRA-CEREBRAL NIGRAL TRANSPLANTS [J].
BJORKLUND, A ;
STENEVI, U .
BRAIN RESEARCH, 1979, 177 (03) :555-560
[6]  
BLAM SB, 1988, ONCOGENE, V3, P129
[7]   MONITORING OF CELL VIABILITY IN SUSPENSIONS OF EMBRYONIC CNS TISSUE AND ITS USE AS A CRITERION FOR INTRACEREBRAL GRAFT-SURVIVAL [J].
BRUNDIN, P ;
ISACSON, O ;
BJORKLUND, A .
BRAIN RESEARCH, 1985, 331 (02) :251-259
[8]  
Brundin P, 1987, PROG BRAIN RES <D>, V71, P293
[9]  
ENGELE J, 1991, J NEUROSCI, V11, P3070
[10]   NIMODIPINE ENHANCES GROWTH AND VASCULARIZATION OF NEURAL GRAFTS [J].
FINGER, S ;
DUNNETT, SB .
EXPERIMENTAL NEUROLOGY, 1989, 104 (01) :1-9