HYPOTHERMIC PREVENTION OF NUCLEAR-DNA FRAGMENTATION IN GERBIL HIPPOCAMPUS FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA

被引：19

作者：

HARA, A

YOSHIMI, N

MORI, H

IWAI, T

SAKAI, N

YAMADA, H

NIWA, M

机构：

[1] GIFU UNIV,SCH MED,DEPT NEUROSURG,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,DEPT PHARMACOL,GIFU 500,JAPAN

来源：

NEUROLOGICAL RESEARCH | 1995年 / 17卷 / 06期

关键词：

DELAYED NEURONAL DEATH; DNA FRAGMENTATION; HYPOTHERMIA; CEREBRAL ISCHEMIA; GERBIL; HIPPOCAMPUS;

D O I：

10.1080/01616412.1995.11740364

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The protective effect of hypothermia on DNA fragmentation following transient forebrain ischemia in mongolian gerbils was investigated. The DNA fragmentation demonstrated in situ in gerbil hippocampal CA1 was compared between intra- and post-ischemic hypothermia. Intraischemic hypothermia prevented the DNA fragmentation in hippocampal CA1 completely, while severe DNA damage was observed in post-ischemic hypothermia group. The degree of DNA fragmentation of hippocampal CA1 in the post-ischemic hypothermia group was equal to that in the ischemic control group. The results suggest that hypothermia during a transient forebrain ischemia exerts a protective effect on the post-ischemic hippocampal damage by preventing the DNA fragmentation in CA1 neurons.

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页码：461 / 464

页数：4

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