NP-06 - A NOVEL ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS POLYPEPTIDE PRODUCED BY A STREPTOMYCES SPECIES

被引：33

作者：

CHOKEKIJCHAI, S

KOJIMA, E

ANDERSON, S

NOMIZU, M

TANAKA, M

MACHIDA, M

DATE, T

TOYOTA, K

ISHIDA, S

WATANABE, K

YOSHIOKA, H

ROLLER, PP

MURAKAMI, K

MITSUYA, H

机构：

[1] NCI,DIV CANC TREATMENT,MED BRANCH,EXPTL RETROVIRUS SECT,BETHESDA,MD 20892

[2] NCI,DIV CANC TREATMENT,MED CHEM LAB,BETHESDA,MD 20892

[3] NHLBI,HEMATOL BRANCH,BETHESDA,MD 20892

[4] NIDR,DEV BIOL LAB,BETHESDA,MD 20892

[5] NIPPON PAPER IND CO LTD,BIOSCI RES LAB,IWAKUNI,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 10期

关键词：

D O I：

10.1128/AAC.39.10.2345

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

From an extract of a Streptomyces culture, we identified and purified a novel compound, NP-06, which is active against human immunodeficiency virus (HIV) in vitro. Analyses indicate that NP-06 is a hydrophobic 21-mer oligopeptide, N terminally cyclized through the side chain of Asp-9, containing two intramolecular cystine linkages with a molecular weight of 2,163.4. The 50% inhibitory concentrations were 2.8 and 1.3 mu M when NP-06 was tested for in vitro anti-HIV-1 activity in ATH8 cells and phytohemagglutinin activated peripheral blood mononuclear cells, respectively. NP-06 appears to block the early stage of HIV-1 infection, most likely at the stage of virus-cell fusion.

引用

页码：2345 / 2347

页数：3

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