PARTICIPATION BY PURINES IN THE MODULATION OF NOREPINEPHRINE RELEASE BY METHOXAMINE

被引：41

作者：

SHINOZUKA, K ^{[1
]}

SEDAA, KO ^{[1
]}

BJUR, RA ^{[1
]}

WESTFALL, DP ^{[1
]}

机构：

[1] UNIV NEVADA,SCH MED,DEPT PHARMACOL,RENO,NV 89557

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 03期

关键词：

ARTERY (CAUDAL); NOREPINEPHRINE; NEUROMODULATION; METHOXAMINE; ADENINE NUCLEOTIDES; ADENINE NUCLEOSIDES;

D O I：

10.1016/0014-2999(91)90236-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The alpha-1-receptor agonist methoxamine reduced, by a prazosin sensitive mechanism, the nerve stimulation evoked release of norepinephrine in the rat caudal artery. The effect of methoxamine was also antagonized by the purinoceptor antagonist 8-(p-sulfophenyl)theophylline suggesting an involvement of endogenous purines in this process. Indeed, methoxamine caused the release of adenine nucleotides and adenosine, an action which was blocked by prazosin. These results suggest that methoxamine releases ATP or a related purine which in turn decreases transmitter release by acting on prejunctional purinoceptors.

引用

页码：431 / 434

页数：4

共 10 条

[1] THE ENDOTHELIUM MODULATES ADRENERGIC NEUROTRANSMISSION TO CANINE PULMONARY-ARTERIES AND VEINS [J].