IMMUNE-RESPONSE OF CLUN FOREST SHEEP TO VACCINATION WITH MEMBRANE-GLYCOPROTEINS FROM HAEMONCHUS-CONTORTUS

被引：39

作者：

TAVERNOR, AS ^{[1
]}

SMITH, TS ^{[1
]}

LANGFORD, CF ^{[1
]}

GRAHAM, M ^{[1
]}

MUNN, EA ^{[1
]}

机构：

[1] AFRC,INST ANIM PHYSIOL & GENET RES,DEPT IMMUNOL,CAMBRIDGE RES STN,CAMBRIDGE CB2 4AT,ENGLAND

来源：

PARASITE IMMUNOLOGY | 1992年 / 14卷 / 06期

关键词：

HAEMONCHUS-CONTORTUS; IMMUNE RESPONSE; MEMBRANE GLYCOPROTEINS; VACCINATION;

D O I：

10.1111/j.1365-3024.1992.tb00038.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clun Forest lambs were injected with a fraction containing integral membrane glycoproteins derived from the intestinal microvilli of Haemonchus contortus in two equal doses of 0-5, 5, 50 or 500 mug protein and then challenged with 10 000 infective larvae. The time-course of serum specific antibody responses were determined. Compared to the adjuvant control group, the animals injected with 1 000 mug protein were better than 84% protected and those injected with 100 mug, better than 95% protected by all criteria. For these two groups parasite egg output was reduced 99% on average over the patent period. Two of the animals injected with 10 ug protein were partially protected, with 86% reduction in egg output. Two animals in the group injected with 1 mug protein also showed partial protection. Antibody level correlated with protection.

引用

页码：671 / 675

页数：5

共 5 条

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[5]

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