EFFECT OF THE ANTIMALARIAL AGENTS PRIMAQUINE AND (N'-3-ACETYL-4-5-DIHYDRO-2-FURANYL)-N4-(6-METHOXY-8-QUINOLINYL)1,4-PENTANE-DIAMINE ON OXIDATIVE STRESS AND ANTIOXIDANT DEFENSES IN MICE

The effects of the newly developed antimalarial compound, CDRI 80/53 [(N'-3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentane-diamine], and primaquine (PQ) on the antioxidant system of mice were determined at equi-effective antimalarial doses on enzyme systems responsible for protection against oxygen, i.e. hepatic superoxide dismutase and catalase. While PQ significantly inhibited these enzyme activities CDRI 80/53 did not. However, both compound 80/53 and PQ increased the level of superoxide anion and lipid peroxidation. It is concluded that compound 80/53 has less effect on antioxidant defence enzymes than PQ.