PREDICTED STRUCTURE AND POSSIBLE IONMOTIVE MECHANISM OF THE SODIUM-LINKED NADH-UBIQUINONE OXIDOREDUCTASE OF VIBRIO-ALGINOLYTICUS

被引：69

作者：

RICH, PR

MEUNIER, B

WARD, FB

机构：

[1] GLYNN RES FDN, BODMIN PL30 4AU, CORNWALL, ENGLAND

[2] UNIV EDINBURGH, INST CELL & MOLEC BIOL, EDINBURGH, MIDLOTHIAN, SCOTLAND

来源：

FEBS LETTERS | 1995年 / 375卷 / 1-2期

关键词：

NADH-UBIQUINONE OXIDOREDUCTASE; NADH DEHYDROGENASE; SODIUM ION TRANSLOCATION;

D O I：

10.1016/0014-5793(95)01164-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two groups have now published sequences of the six genes contained in the operon coding for the sodium-linked NADH-ubiquinone oxidoreductase of Vibrio alginolyticus. Sequence analyses indicate that this enzyme is unrelated to other known respiratory NADH dehydrogenases, A search for cofactor motifs suggests that the enzyme contains only one FAD, a ferredoxin-type iron sulphur centre, and the NADH-binding site. These are all located on NqrF, a subunit that can be recognized as a new member of a large diverse family of NAD(P)H-oxidizing flavoenzymes. A possible model of ion-coupling is presented, based upon this new information.

引用

收藏

页码：5 / 10

页数：6

相关论文

共 42 条

[1] AG+-SENSITIVE NADH DEHYDROGENASE IN THE NA+-MOTIVE RESPIRATORY-CHAIN OF THE MARINE BACTERIUM VIBRIO-ALGINOLYTICUS [J].

ASANO, M ;

HAYASHI, M ;

UNEMOTO, T ;

TOKUDA, H .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (09) :2813-2817

[2] CLONING AND SEQUENCING OF 4 STRUCTURAL GENES FOR THE NA+-TRANSLOCATING NADH-UBIQUINONE OXIDOREDUCTASE OF VIBRIO-ALGINOLYTICUS [J].

BEATTIE, P ;

TAN, K ;

BOURNE, RM ;

LEACH, D ;

RICH, PR ;

WARD, FB .

FEBS LETTERS, 1994, 356 (2-3) :333-338

[3] CHARACTERIZATION OF A SODIUMMOTIVE NADH - UBIQUINONE OXIDOREDUCTASE [J].

BOURNE, RM ;

RICH, PR .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (03) :577-582

[4] PHTHALATE DIOXYGENASE REDUCTASE - A MODULAR STRUCTURE FOR ELECTRON-TRANSFER FROM PYRIDINE-NUCLEOTIDES TO [2FE-2S] [J].

CORRELL, CC ;

BATIE, CJ ;

BALLOU, DP ;

LUDWIG, ML .

SCIENCE, 1992, 258 (5088) :1604-1610

[5]

DEVRIES S, 1992, EUR J BIOCHEM, V203, P587

[6] IDENTIFICATION OF 2 GENES OF RHODOBACTER-CAPSULATUS CODING FOR PROTEINS HOMOLOGOUS TO THE ND1 AND 23 KDA SUBUNITS OF THE MITOCHONDRIAL COMPLEX-I [J].

DUPUIS, A .

FEBS LETTERS, 1992, 301 (02) :215-218

[7] CONSERVATION OF SEQUENCES OF SUBUNITS OF MITOCHONDRIAL COMPLEX-I AND THEIR RELATIONSHIPS WITH OTHER PROTEINS [J].

FEARNLEY, IM ;

WALKER, JE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1140 (02) :105-134

[8] DIVERGENT EVOLUTION OF CHLOROPLAST-TYPE FERREDOXINS [J].

HARAYAMA, S ;

POLISSI, A ;

REKIK, M .

FEBS LETTERS, 1991, 285 (01) :85-88

[9] POTENTIAL DNA SLIPPAGE STRUCTURES ACQUIRED DURING EVOLUTIONARY DIVERGENCE OF ACINETOBACTER-CALCOACETICUS CHROMOSOMAL BENABC AND PSEUDOMONAS-PUTIDA TOL PWWO PLASMID XYLXYZ, GENES ENCODING BENZOATE DIOXYGENASES [J].

HARAYAMA, S ;

REKIK, M ;

BAIROCH, A ;

NEIDLE, EL ;

ORNSTON, LN .

JOURNAL OF BACTERIOLOGY, 1991, 173 (23) :7540-7548

[10]

HARAYAMA S, 1991, J BACTERIOL, V173, P5385

← 1 2 3 4 5 →