CHEMOTHERAPY AND IRRADIATION IN CHILDHOOD HODGKINS-DISEASE

Children (80) aged < 16 yr with newly diagnosed Hodgkin''s disease were treated between 1974-1982. Complete remission occurred in 95%, with actuarial 5 yr overall survival of 94%, and relapse free survival of 82%: median follow-up was 4.8 yr. Of these 61 children were staged clinically while 19 had staging laparotomies before treatment. Most received combined modality treatment with Ch1VPP chemotherapy (chlorambucil, vinblastine, procarbazine and prednisolone) followed by irradiation of initial bulk disease. Nodular sclerosis predominated in both sexes, accounting for 60% of the total. Girls with stage IV disease, nodal sclerosis histology and bulky mediastinal masses had a relatively poor prognosis. Ten children have relapsed, and 3 prolonged (6-7 yr) second remissions were observed. Four died of disease and 1 from infection. Clinical staging, avoiding splenectomy, reduced the risk of serious infections. Current policy is to treat stage IA disease with local irradiation and all other stages with chemotherapy, adding irradiation for bulky mediastinal disease.