6-[F-18]FLUORO-L-DOPA METABOLISM IN MPTP-TREATED MONKEYS - ASSESSMENT OF TRACER METHODOLOGIES FOR POSITRON EMISSION TOMOGRAPHY

被引：34

作者：

MELEGA, WP

HOFFMAN, JM

SCHNEIDER, JS

PHELPS, ME

BARRIO, JR

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,DIV NUCL MED & BIOPHYS,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,NUCL MED LAB,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1991年 / 543卷 / 02期

关键词：

L-3,4-DIHYDROXY-6-[F-18]FLUOROPHENYLALANINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; DOPAMINE METABOLISM; PARKINSONS DISEASE; MONKEY BRAIN;

D O I：

10.1016/0006-8993(91)90037-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

6-[F-18]Fluoro-L-DOPA (FDOPA) is an L-DOPA analog that is used to assess the functional integrity of central dopaminergic systems in vivo with positron emission tomography (PET). FDOPA metabolites from putamen of normal and MPTP-treated monkeys were characterized to correlate FDOPA metabolism changes with those of the endogenous dopamine system. In MPTP-lesioned putamen, 6-[F-18]fluorodopamine and dopamine levels were less than 2% those of controls. Increases in endogenous dopamine metabolism were reflected by similar increases in 6-[F-18]fluorodopamine metabolites. These results suggest that changes in the central dopamine system biochemistry can be monitored in vivo with FDOPA and PET.

引用

页码：271 / 276

页数：6

共 20 条

[1] BARRIO JR, 1988, ANNU REV PHARMACOL, V28, P213
[2] POSITRON EMISSION TOMOGRAPHY AFTER MPTP - OBSERVATIONS RELATING TO THE CAUSE OF PARKINSONS-DISEASE
CALNE, DB
LANGSTON, JW
MARTIN, WRW
STOESSL, AJ
RUTH, TJ
ADAM, MJ
PATE, BD
SCHULZER, M
[J]. NATURE, 1985, 317 (6034) : 246 - 248
[3] CHIUEH CC, 1986, ADV NEUROL, V45, P167
[4] CUMMING P, 1987, J NEUROCHEM, V48, P601
[5] DOUDET DJ, 1989, EXP BRAIN RES, V78, P69
[6] FIRNAU G, 1987, J NEUROCHEM, V48, P107
[7] CHANGES IN SPECIFIC ACTIVITY OF DOPAMINE METABOLITES AS EVIDENCE OF A MULTIPLE COMPARTMENTATION OF DOPAMINE IN STRIATAL NEURONS
GROPPETTI, A
ALGERI, S
CATTABENI, F
DIGIULIO, AM
GALLI, CL
PONZIO, F
SPANO, PF
[J]. JOURNAL OF NEUROCHEMISTRY, 1977, 28 (01) : 193 - 197
[8] HOFFMAN JM, 1989, J CEREB BLOOD FLO S1, V9, P5734
[9] LANGSTON JW, 1987, PHARMACOL THERAPEUT, V32, P19
[10] BRAIN DOPAMINE METABOLISM IN PATIENTS WITH PARKINSONS-DISEASE MEASURED WITH POSITRON EMISSION TOMOGRAPHY
LEENDERS, KL
PALMER, AJ
QUINN, N
CLARK, JC
FIRNAU, G
GARNETT, ES
NAHMIAS, C
JONES, T
MARSDEN, CD
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1986, 49 (08) : 853 - 860

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