LOW CONCENTRATIONS OF LITHIUM AND CYCLOOXYGENASE INHIBITORS ENHANCE ENDOTHELIN-1 (ET-1)-INDUCED CONTRACTIONS IN HUMAN TEMPORAL ARTERY, BUT NOT IN PORCINE OPHTHALMIC ARTERY

被引:8
作者
BAKKEN, IJ
VINCENT, MB
WHITE, LR
CAPPELEN, J
SKAANES, KO
SJAASTAD, O
机构
[1] TRONDHEIM REG & UNIV HOSP,DEPT NEUROL,N-7006 TRONDHEIM,NORWAY
[2] TRONDHEIM REG & UNIV HOSP,DEPT NEUROSURG,N-7006 TRONDHEIM,NORWAY
[3] UNIV TRONDHEIM,DEPT PHYS,BIOPHYS GRP,TRONDHEIM,NORWAY
[4] FED UNIV RIO DE JANEIRO,UNIV HOSP,DEPT NEUROL,BR-21949 RIO JANEIRO,BRAZIL
来源
HEADACHE | 1992年 / 32卷 / 10期
关键词
ENDOTHELIN; LITHIUM; CYCLOOXYGENASE INHIBITORS;
D O I
10.1111/j.1526-4610.1992.hed3210475.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Endothelins are a recently discovered group of potent vasoconstrictor peptides synthesized by endothelial cells and other tissues in various species, which seem to participate in the regulation of vascular tonus. Abnormalities in vasoactivity in the head may be an important event in headache pathophysiology, although the mechanisms responsible for such constrictions and/or dilations are not known. The endothelium and its constrictor peptide, endothelin, may play a key role in such mechanisms. Of the various drugs used in the treatment of headache, lithium is an accepted treatment for cluster headache, and indomethacin is the drug of choice for the associated condition chronic paroxysmal hemicrania. The mechanism of action of these drugs in these headaches is not known. Due to the possible involvement of endothelin in headache disorders, the objective of this study was to verify the effects of lithium and cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid and naproxen) on endothelin-1 (ET-1)-induced contractions in isolated human temporal arteries and porcine ophthalmic arteries. It was found that all drugs increased the (ET-1)-induced contractions in human temporal arteries. Conversely, there were no significant changes induced by the drugs in porcine ophthalmic arteries. These results are consistent with the variation of activity often seen in different vascular beds and between species. The potential importance of such reactions for the understanding of vascular changes putatively involved in headache development and treatment is discussed.
引用
收藏
页码:475 / 479
页数:5
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