THE S-ANTIGEN OF PLASMODIUM-FALCIPARUM - REPERTOIRE AND ORIGIN OF DIVERSITY

被引：17

作者：

BICKLE, Q ^{[1
]}

ANDERS, RF ^{[1
]}

DAY, K ^{[1
]}

COPPEL, RL ^{[1
]}

机构：

[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1993年 / 61卷 / 02期

关键词：

PLASMODIUM-FALCIPARUM; S-ANTIGEN; ANTIGENIC DIVERSITY; SEROTYPING; REPEAT;

D O I：

10.1016/0166-6851(93)90065-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-antigens are heat-stable, highly polymorphic proteins released by Plasmodium falciparum at the time of schizont rupture. Previously determined S-antigen sequences allowed the proposal of a general gene structure consisting of 5 sequence blocks. The sequence of the central block of tandem repeats provides a useful means of distinguishing the S-antigen allele and also its serotype, whereas the amino and carboxy terminal sequences defined the S-antigen family, 4 of which have been described. We present the sequence of 3 new S-antigen alleles, for the isolates HB3, KF1916 and KF1917. The allele-defining repeat sequence is ETGPGKAGEQG for HB3, GDQTEGS(S/A)GGK for KF1917 and AGSNE(E/K) for KF1916. The sequences of these newly described S-antigens are consistent with the proposed general gene structure and all belong to defined families, although carboxy-terminal sequences appear to be much more variable within a family than previously realised.

引用

页码：189 / 196

页数：8

共 24 条

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