ORAL VACCINATION OF RACOONS (PROCYON-LOTOR) WITH BACULOVIRUS-EXPRESSED RABIES VIRUS GLYCOPROTEIN

被引：34

作者：

FU, ZF ^{[1
]}

RUPPRECHT, CE ^{[1
]}

DIETZSCHOLD, B ^{[1
]}

SAIKUMAR, P ^{[1
]}

NIU, HS ^{[1
]}

BABKA, I ^{[1
]}

WUNNER, WH ^{[1
]}

KOPROWSKI, H ^{[1
]}

机构：

[1] WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

来源：

VACCINE | 1993年 / 11卷 / 09期

关键词：

RABIES; BACULOVIRUS; GLYCOPROTEIN; ORAL VACCINATION; WILDLIFE;

D O I：

10.1016/0264-410X(93)90379-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Successful field oral vaccination and protection against viral diseases have so far been achieved only with live-attenuated or live-recombinant virus vaccines. In this communication, we present data that demonstrate that a glycoprotein derived from recombinant baculovirus-infected insect cells is efficacious as an oral vaccine. The glycoprotein (G) of rabies virus (Evelyn Rokitnicki Abelseth strain) was abundantly expressed in a baculovirus expression system and oral vaccination of racoons with the baculovirus-expressed G protein resulted in the production of rabies virus-neutralizing antibodies and protection against a lethal challenge with a street rabies virus. The potential for using the baculovirus-expresssed G protein for oral immunization of wildlife is discussed.

引用

页码：925 / 928

页数：4

共 20 条

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