EFFECT OF NEONATAL MONOSODIUM GLUTAMATE ON LIPID-PEROXIDATION IN ADULT-RAT BRAIN

被引：16

作者：

BAWARI, M

BABU, GN

ALI, MM

MISRA, UK

机构：

[1] SANJAY GANDHI POSTGRAD INST MED SCI,DEPT NEUROL,LUCKNOW 226014,UTTAR PRADESH,INDIA

[2] IND TOXICOL RES CTR,DIV NEUROTOXICOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

NEUROREPORT | 1995年 / 6卷 / 04期

关键词：

MONOSODIUM GLUTAMATE; LIPID PEROXIDATION; CATALASE; SULFHYDRYL GROUPS; EXCITOTOXINS; FREE RADICALS;

D O I：

10.1097/00001756-199503000-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLUTAMATE (glu), an excitatory amino acid (EAA) abundantly present in the brain of mammals, is also a neurotoxin. We examined lipid peroxidation (LPO) potential and antioxidant parameters of midbrain region (MBR) and frontal cortex of adult rats following treatment with monosodium glutamate (MSG) during postnatal day (PND) 1 through PND 10 at a daily dose of 4 mg g(-1) body weight. In PND 90 rats MSG increased LPO by 56% and altered antioxidant status of MBR. This indicates that oxidative stress produced by glu in vulnerable brain regions may persist for prolonged periods and could be one of the mechanisms of EAA neurotoxicity resulting in chronic neurodegeneration.

引用

页码：650 / 652

页数：3

共 21 条

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