PHOTODEGRADATION OF SOME QUINOLONES USED AS ANTIMICROBIAL THERAPEUTICS

被引：61

作者：

TIEFENBACHER, EM ^{[1
]}

HAEN, E ^{[1
]}

PRZYBILLA, B ^{[1
]}

KURZ, H ^{[1
]}

机构：

[1] UNIV MUNICH,DEPT DERMATOL,D-80337 MUNICH,GERMANY

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 04期

关键词：

D O I：

10.1002/jps.2600830403

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The photostability of the fluoroquinolones ciprofloxacin (CPX), ofloxacin (OFX), and fleroxacin (FLX) toward ultraviolet irradiation (UVA) and room light was investigated in dilute aqueous solutions. A series of photoproducts was observed by high-performance liquid chromatography (HPLC) for all three drugs. As little as 1 h of exposure to room light was enough for the formation of detectable amounts of CPX photoproducts. The major CPX photoproduct was characterized as a dimer by liquid secondary ion mass spectrometry, but its structure was not determined. Since irradiation of CPX results (as cited in ref/11)in a loss of antibacterial activity and since all substances, parent drugs as well as their photoproducts, are potential candidates for undesired drug effects, quinolone drugs should be strictly protected from all light during storage and administration.

引用

页码：463 / 467

页数：5

共 19 条

[1] PHOTOONYCHOLYSIS INDUCED BY THE FLUOROQUINOLONES PEFLOXACINE AND OFLOXACINE - REPORT ON 2 CASES [J].