NORMAL GENETIC RESPONSE TO GAMMA-IRRADIATION IN FAMILIAL ADENOMATOUS POLYPOSIS

被引：3

作者：

BRAS, A

CRISTOVAO, L

COELHO, C

HILALI, A

DUTRILLAUX, B

LEONARD, A

RUEFF, J

机构：

[1] UNIV NOVA LISBOA, FAC MED SCI, DEPT GENET, P-1300 LISBON, PORTUGAL

[2] UNIV CATHOLIQUE LOUVAIN, FAC MED, MUTAGEN & TERATOGEN UNIT, B-1200 BRUSSELS, BELGIUM

[3] INST CURIE, CNRS, URA 620, F-75231 PARIS 05, FRANCE

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 09期

关键词：

CHROMOSOMAL ABERRATIONS; DNA STRAND BREAKS; GAMMA RAYS; POLY(ADP-RIBOSE) POLYMERASE; FAMILIAL ADENOMATOUS POLYPOSIS;

D O I：

10.1016/0959-8049(95)00247-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study, a co-operative project between three European institutes, was aimed at elucidating whether the APC gene in carriers of familial adenomatous polyposis coli (FAP) also causes some genetic sensitivity revealed by DNA damage and the yield of chromosome aberrations in peripheral blood lymphocytes exposed to gamma rays. In addition, it seemed of interest to study whether DNA repair is modified after irradiation of lymphocytes from FAP patients compared to controls. To this end, we have used the inhibition of the poly(ADP-ribose) polymerase (ADPRP) by 3-aminobenzamide (3ABA) and studied the effect of 3ABA on the frequency of DNA strand breaks and chromosome aberrations. The data indicate that FAP is not associated with an increased chromosomal sensitivity towards ionising radiation.

引用

页码：1506 / 1510

页数：5

共 15 条

[1] BAN S, 1983, RAD EFF RES F, P17
[2] BIRNBOIM HC, 1981, CANCER RES, V41, P1889
[3] GENETICS, MOLECULAR-BIOLOGY AND COLORECTAL-CANCER
FINLAY, GJ
[J]. MUTATION RESEARCH, 1993, 290 (01): : 3 - 12
[4] POLY(ADP-RIBOSYLATION) AS TARGET FOR CANCER-CHEMOTHERAPY
JUDSON, IR
THREADGILL, MD
[J]. LANCET, 1993, 342 (8872) : 632 - 632
[5] COMPARISON OF RADIATION-INDUCED CHROMOSOMAL DAMAGE BETWEEN NORMAL INDIVIDUALS AND PATIENTS WITH FAMILIAL POLYPOSIS COLI
KAKATI, S
HERRERA, L
DRURY, RE
SANDBERG, AA
[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1988, 114 (03) : 297 - 300
[6] FAMILIAL POLYPOSIS COLI - NO EVIDENCE FOR INCREASED SENSITIVITY TO MITOMYCIN-C
MAZZULLO, HA
ATTWOOD, J
DELHANTY, JDA
[J]. JOURNAL OF MEDICAL GENETICS, 1988, 25 (04) : 233 - 237
[7] OVERPRODUCTION OF THE POLY(ADP-RIBOSE) POLYMERASE DNA-BINDING DOMAIN BLOCKS ALKYLATION-INDUCED DNA-REPAIR SYNTHESIS IN MAMMALIAN-CELLS
MOLINETE, M
VERMEULEN, W
BURKLE, A
MENISSIERDEMURCIA, J
KUPPER, JH
HOEIJMAKERS, JHJ
DEMURCIA, G
[J]. EMBO JOURNAL, 1993, 12 (05) : 2109 - 2117
[8] MORGAN WF, 1983, CANCER RES, V43, P3104
[9] CARCINOGENIC FACTORS IN FOOD WITH RELEVANCE TO COLON-CANCER DEVELOPMENT
NAGAO, M
SUGIMURA, T
[J]. MUTATION RESEARCH, 1993, 290 (01): : 43 - 51
[10] PERO RW, 1990, CANCER RES, V50, P4619

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