INCREASED FREQUENCY OF 6-THIOGUANINE-RESISTANT LYMPHOCYTES IN PERIPHERAL-BLOOD OF WORKERS EMPLOYED IN CYCLOPHOSPHAMIDE PRODUCTION

被引：29

作者：

HUTTNER, E ^{[1
]}

MERGNER, U ^{[1
]}

BRAUN, R ^{[1
]}

SCHONEICH, J ^{[1
]}

机构：

[1] MARTIN LUTHER UNIV,SCH MED,INST BIOL,O-4020 HALLE,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 243卷 / 02期

关键词：

Cyclophosphamide; HPRT-deficient variant frequency; occupational exposure to; Peripheral lymphocytes;

D O I：

10.1016/0165-7992(90)90030-N

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The frequency of 6-thioguanine-resistant peripheral blood lymphocytes has been determined by autoradiography in a control population and a population of cyclophosphamide-exposed individuals. The mean variant frequency in a non-exposed population was found to be 2.76 ± 1.48 × 10-5. Subpopulations of smokers and non-smokers revealed statistically significantt differences in the variant frequencies, i.e. 3.52 ± 1.55 × 10-5 and 2.07 ± 1.05 × 10-5 respectively. In 20 out of a total of 23 individuals employed in cyclophosphamide synthesis and manufacturing, the variant frequency of 6-thioguanine-resistant lymphocytes was found to be higher than the maximum individual frequency found in the control population. The mean variant frequency in the cyclophosphamide-exposed population was 13.64 ± 13.56 × 10-5, a statistically significant increase as compared to the mean control frequency. There was no correlation between variant frequency and duration of employment suggesting that this test reflects the actual exposure and not a cumulative effect. © 1990.

引用

页码：101 / 107

页数：7

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