CIRCADIAN VARIATIONS IN BLOOD-COAGULATION PARAMETERS, ALPHA-ANTITRYPSIN ANTIGEN AND PLATELET-AGGREGATION AND RETENTION IN CLINICALLY HEALTHY-SUBJECTS

被引：94

作者：

HAUS, E

CUSULOS, M

SACKETTLUNDEEN, L

SWOYER, J

机构：

[1] St. Paul-Ramsey Medical Center, Ramsey Clinic, University of Minnesota, St Paul, MN

来源：

CHRONOBIOLOGY INTERNATIONAL | 1990年 / 7卷 / 03期

关键词：

Activated thromboplastin time; Adhesiveness; Alpha-1-antitrypsin; Alpha-2-macroglobulin; Antithrombin III; Circadian rhythm; Factors V and VIII; Fibrogen; Key words-Blood coagulation; Platelet aggregation; Prothrombin time; Thrombin time;

D O I：

10.3109/07420529009056976

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ten clinically healthy subjects (5 men and 5 women), 31 11 yrs of age, were studied at six timepoints (0800, 1200, 1600, 2000, 0000, 0400) distributed over a 1-week span. Circadian rhythms in platelet aggregation in response to adenosine diphosphate (ADP) and adrenalin (A), platelet adhesiveness measured as retention in a glass bead column, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen, Factor VIII activity and alpha-1-antitrypsin antigen showed circadian rhythms. The plasma concentrations of plasminogen, alpha-2-macroglobulin, and antithrombin III (AT III) antigen, Factor V and fibrinogen degradation products showed no circadian rhythm by ANOVA or cosinor analysis. The phase relations of the rhythms of different coagulation parameters are of interest in the physiology and pathobiology of the coagulation-fibrinolytic system. The extent of the circadian rhythm (range of change) described is not of a magnitude to lead to diagnostic problems in the clinical laboratory. The timing of these rhythms, however, may determine transient risk states for thromboembolic phenomena, including myocardial infarction and stroke. Several but not all coagulation parameters suggest a transient state of hypercoagulability during the morning hours. The recognition of these rhythmic, and thus in the time of the occurrence predictable temporary risk states for thromboembolic phenomena, may lead to timed treatment and/or effective prevention. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：203 / 216

页数：14

共 43 条

[1]

Master A.M., Jaffee J.L., Factors in the onset of coronary occlusion and coronary insufficiency, J Am Med Assn, 148, pp. 794-798, (1952)

[2]

Reinberg A., Gervais P., Halberg F., Gaultier M., Poynette N., Abulker N., Dupont J., Mortalite des adultes. Rhythms Circadiens et Circanuels, Now Presse Med, 2, pp. 289-294, (1973)

[3]

Muller J.E., Stone P.H., Turi S.G., Rutherford J.D., Czeisler C.A., Parker C., Poole W.K., Passaraani E., Roberts R., Robertson T., Sobel B.E., Willerson J.T., Braunwald E., Circadian variation in the frequency of onset of acute myocardial infarction, N Eng J Med, 313, pp. 1315-1322, (1985)

[4]

Muller J.E., Ludmer P.L., Willich N., Tofler G.H., Aylmer G., Klangos I., Stone P.E., Circadian variation in the frequency of sudden cardiac death, Circulation, 75, pp. 131-138, (1987)

[5]

Rabkin S.O., Mathewson F.A.L., Tate R.B., Chronobiology of cardiac sudden death in men, J Am Med Assoc, 244, pp. 1357-1358, (1980)

[6]

Marshall J., Diurnal variation in the occurrence of strokes, Stroke, 8, pp. 230-231, (1977)

[7]

Marler J.R., Price T.R., Clark G.L., Muller J.E., Robertson T., Mohr J.P., Hier D.B., Wolf P.A., Caplan L.R., Foulkes M.A., Morning increase in onset of ischemic stroke, Stroke, 20, pp. 473-476, (1989)

[8]

Ramirez-Lassepas M., Haus E., Lakatua D.J., Sackett-Lundeen L., Swoyer J., Circadian variation in time of onset of acute intracerebral hemorrhage

[9]

Cohen M.S., The coagulation time of blood as affected by various conditions, Arch Int Med, 8, pp. 684-716, (1911)

[10]

Petralito A., Mangiafico R.A., Gibiino S., Cuffari M.A., Miano M.F., Fiore C.E., Daily modifications of plasma fibrinogen, platelets aggregation, Howell's time, PTT, TT and antithrombin III in normal subjects and in patients with vascular disease, Chronobiologia, 9, pp. 195-201, (1982)

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