BIOLOGICAL-ACTIVITY OF N-TERMINAL FRAGMENTS OF CALCITONIN GENE-RELATED PEPTIDE

被引：44

作者：

MAGGI, CA

ROVERO, P

GIULIANI, S

EVANGELISTA, S

REGOLI, D

MELI, A

机构：

[1] A MENARINI PHARMACEUT,DEPT CHEM,I-50131 FLORENCE,ITALY

[2] UNIV SHERBROOKE,DEPT PHARMACOL,SHERBROOKE J1K 2R1,QUEBEC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 179卷 / 1-2期

关键词：

Blood pressure (rat); CGRP (calcitonin gene-related peptide); Cyclic peptides (N-terminal fragments);

D O I：

10.1016/0014-2999(90)90422-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The i.v. injection of human α-calcitonin gene-related peptide (CGRP) in urethane-anesthetized rats produced hypotension and tachycardia. The N-terminal fragments, CGRP-(1-12), CGRP-(1-15) and CGRP-(1-22) displayed biological activity, although with less potency than the natural peptide. These findings provide the first evidence for biological agonist activity of N-terminal CGRP fragments. © 1990.

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页码：217 / 219

页数：3

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