NITRIC-OXIDE EVOKES PAIN IN HUMANS ON INTRACUTANEOUS INJECTION

被引：83

作者：

HOLTHUSEN, H

ARNDT, JO

机构：

[1] Heinrich-Heine-Universität Düsseldorf, Institut für Experimentelle Anaesthesiologie, 40001 Düsseldorf

来源：

NEUROSCIENCE LETTERS | 1994年 / 165卷 / 1-2期

关键词：

NOCICEPTION; NITRIC OXIDE; HUMAN;

D O I：

10.1016/0304-3940(94)90712-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To test the hypothesis that nitric oxide (NO) acts algetically in humans, we determined pain intensity/dose relations for intracutaneously applied NO solutions. NO, dissolved in isoosmolar phosphate buffer, was injected in the forearm of six volunteers and the subjects rated NO-evoked pain continuously with the help of an electronically controlled visual analogue scale. Pain always occurred at a NO dose of 12 nmol, increased with dose and reached the tolerance maximum at 50 nmol. This shows for the first time the genuine pain evoking properties of NO.

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页码：71 / 74

页数：4

相关论文

共 16 条

[1] OBSERVATIONS ON CHEMICAL EXCITANTS OF CUTANEOUS PAIN IN MAN [J].

ARMSTRONG, D ;

DRY, RML ;

KEELE, CA ;

MARKHAM, JW .

JOURNAL OF PHYSIOLOGY-LONDON, 1953, 120 (03) :326-351

[2] THE MOLECULAR MECHANISM OF CENTRAL ANALGESIA INDUCED BY MORPHINE OR CARBACHOL AND THE L-ARGININE-NITRIC OXIDE-CGMP PATHWAY [J].

DUARTE, IDG ;

FERREIRA, SH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 221 (01) :171-174

[3] THE MOLECULAR MECHANISM OF ACTION OF PERIPHERAL MORPHINE ANALGESIA - STIMULATION OF THE CGMP SYSTEM VIA NITRIC-OXIDE RELEASE [J].

FERREIRA, SH ;

DUARTE, IDG ;

LORENZETTI, BB .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 201 (01) :121-122

[4] ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT [J].

HALEY, JE ;

DICKENSON, AH ;

SCHACHTER, M .

NEUROPHARMACOLOGY, 1992, 31 (03) :251-258

[5]

Harima A, 1991, Eur Neuropsychopharmacol, V1, P529, DOI 10.1016/0924-977X(91)90006-G

[6] L-LEUCYL-L-ARGININE, NALTRINDOLE AND D-ARGININE BLOCK ANTINOCICEPTION ELICITED BY L-ARGININE IN MICE WITH CARRAGEENAN-INDUCED HYPERALGESIA [J].

KAWABATA, A ;

NISHIMURA, Y ;

TAKAGI, H .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (04) :1096-1101

[7] ANTINOCICEPTIVE EFFECT OF L-ARGININE ON THE CARRAGEENAN-INDUCED HYPERALGESIA OF THE RAT - POSSIBLE INVOLVEMENT OF CENTRAL OPIOIDERGIC SYSTEMS [J].

KAWABATA, A ;

FUKUZUMI, Y ;

FUKUSHIMA, Y ;

TAKAGI, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 218 (01) :153-158

[8] CONTROL OF CORONARY VASCULAR TONE BY NITRIC-OXIDE [J].

KELM, M ;

SCHRADER, J .

CIRCULATION RESEARCH, 1990, 66 (06) :1561-1575

[9] INVOLVEMENT OF NITRIC-OXIDE IN SPINALLY MEDIATED HYPERALGESIA IN THE MOUSE [J].

KITTO, KF ;

HALEY, JE ;

WILCOX, GL .

NEUROSCIENCE LETTERS, 1992, 148 (1-2) :1-5

[10] NITRIC-OXIDE RELEASE FROM A SINGLE CELL MEASURED INSITU BY A PORPHYRINIC-BASED MICROSENSOR [J].

MALINSKI, T ;

TAHA, Z .

NATURE, 1992, 358 (6388) :676-678