THE CB1 CANNABINOID RECEPTOR ANTAGONIST SR 141716A AFFECTS A(9) DOPAMINE NEURONAL-ACTIVITY IN THE RAT

被引：36

作者：

GUEUDET, C ^{[1
]}

SANTUCCI, V ^{[1
]}

RINALDICARMONA, M ^{[1
]}

SOUBRIE, P ^{[1
]}

LEFUR, G ^{[1
]}

机构：

[1] SANOFI RECH,DEPT NEUROPSYCHIAT,F-34184 MONTPELLIER 04,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 10期

关键词：

CB1; RECEPTOR; SR; 141716A; DOPAMINE NEURONS; APOMORPHINE; AMPHETAMINE;

D O I：

10.1097/00001756-199507100-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CB1 receptors and their putative natural ligand anandamide, have been tentatively involved in the control of midbrain extrapyramidal function. Electrophysiological activity of dopamine neurones was measured after acute and repeated administration of the CB1 receptor antagonist SR 141716A (0.3-3 mg kg(-1)) in rats. Acute SR 141716A increased A(9), but not A(10) cell population response without affecting either their spontaneous firing rate or apomorphine-induced rate inhibition and prevented amphetamine-induced inhibition of A(9), but not of A(10) cell firing. After repeated administration SR 141716A (1 or 5 mg kg(-1)) decreased population response of A(9) cells, which was reversed by apomorphine. These results suggest that CB1 receptor blockade by SR 141716A interrupts a cannabinoid-like endogenous tone controlling extrapyramidal function.

引用

页码：1421 / 1425

页数：5

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