TRANSFORMING GROWTH-FACTOR-BETA-1 LEVELS ARE ELEVATED IN THE STRIATUM AND IN VENTRICULAR CEREBROSPINAL-FLUID IN PARKINSONS-DISEASE

被引：134

作者：

MOGI, M

HARADA, M

KONDO, T

NARABAYASHI, H

RIEDERER, P

NAGATSU, T

机构：

[1] FUJITA HLTH UNIV,INST COMPREHENS MED SCI,TOYOAKE,AICHI,JAPAN

[2] MATSUMOTO DENT COLL,DEPT ORAL BIOCHEM,SHIOJIRI,JAPAN

[3] JUNTENDO UNIV,SCH MED,DEPT NEUROL,TOKYO,JAPAN

[4] UNIV WURZBURG,DEPT PSYCHIAT,WURZBURG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1995年 / 193卷 / 02期

关键词：

TRANSFORMING GROWTH FACTOR-BETA-1; PARKINSONS DISEASE; BRAIN; VENTRICULAR CEREBROSPINAL FLUID;

D O I：

10.1016/0304-3940(95)11686-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transforming growth factor (TGF)-beta 1 content was measured for the first time in the brain (caudate nucleus, putamen, and cerebral cortex) and in ventricular cerebrospinal fluid (VCSF) from control and parkinsonian patients by a sandwich enzyme immunoassay. The concentrations of TGF-beta 1 were significantly higher in the dopaminergic striatal regions in parkinsonian patients than those in controls, but were not significantly different in the cerebral cortex between parkinsonian and control patients. Furthermore, the concentrations of TGF-beta 1 in VCSF were significantly higher in parkinsonian patients than those in non-parkinsonian control patients. Since TGF-beta 1 has potent regulatory activity on cell growth, these results suggest that TGF-beta 1 may have some significant modulatory role in the process of neurodegeneration in Parkinson's disease.

引用

页码：129 / 132

页数：4

共 39 条

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