DECREASED SODIUM-DEPENDENT D-GLUCOSE TRANSPORT ACROSS RENAL BRUSH-BORDER MEMBRANES IN CIS-DIAMMINEDICHLORIDE PLATINUM INDUCED ACUTE-RENAL-FAILURE

被引：12

作者：

YANASE, M ^{[1
]}

UYAMA, O ^{[1
]}

NAKANISHI, T ^{[1
]}

SHIRATSUKI, N ^{[1
]}

SUGITA, M ^{[1
]}

机构：

[1] HYOGO MED UNIV,DEPT INTERNAL MED 5,1-1 MUKOGAWA CHO,NISHINOMIYA,HYOGO 663,JAPAN

来源：

RENAL FAILURE | 1992年 / 14卷 / 01期

关键词：

D O I：

10.3109/08860229209039113

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Na-coupled D-glucose transport in rabbits with cis-diamminedichloride platinum (CDDP; cisplatin) induced acute renal failure (ARF) has been studied. ARF occurred at 3 days after injection of CDDP (3 mg/kg i.v.). Na-coupled D-glucose transport into brush-border membrane vesicles (BBMV) from both outer cortex (OC) and outer medulla (OM) of ARF rabbits under zero-trans condition was decreased. Increased K(m) (i.e., decreased affinity of transport carrier for D-glucose) in OC and decreased V(max) (i.e., decreased number of glucose carrier) in OM were observed in CDDP-induced ARF rabbits. Decreased glucose transport was also observed under equilibrium exchange condition. Intravesicular volume of BBMV from OC and OM of ARF rabbits was decreased. In homogenate and BBMV from OC and OM of ARF rabbits, activities of gamma-glutamyl transpeptidase and alkaline phosphatase (marker enzymes of brush-border membrane) were decreased. Activities of succinate dehydrogenase, glucose-6-phosphatase, and Na-K ATPase (marker enzymes of mitochondria, endoplasmic reticulum, and basal lateral membrane, respectively) were not affected by CDDP administration. These results suggested that one of the main target sites of CDDP in kidney is brush-border membrane (BBM) along the proximal tubule, that is, not only Na-coupled D-glucose transport carrier protein but also other proteins in BBM.

引用

页码：23 / 30

页数：8

共 22 条

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