THE RESPONSE OF TC-99(M)-METHYLENE DIPHOSPHONATE AND TC-99(M)-HEXAMETAZIME-LABELED NEUTROPHILS TO INTRAARTICULAR STEROID INJECTION IN RHEUMATOID-ARTHRITIS

被引：16

作者：

ALJANABI, MA

SOBNACK, R

SOLANKI, KK

JONES, AK

CRITCHLEY, M

SMITH, ML

BRITTON, KE

HUSKISSON, EC

机构：

[1] Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, L7 8XP, I’rescot Street

[2] Departments of Nuclear Medicine, St Bartholomew's Hospital

[3] Departments of Rheumatology, St Bartholomew's Hospital

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1992年 / 13卷 / 07期

关键词：

D O I：

10.1097/00006231-199207000-00008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synovial and bone uptake of tracer in the knees of patients with rheumatoid arthritis (RA) was quantified using Tc-99(m)-hexamethyl propylene amine oxime-labelled leucocytes and Tc-99(m)-methylene diphosphonate (MDP), respectively. Significant neutrophil migration and MDP uptake occurred in the knees of patients with RA irrespective of the disease duration. In all but one patient neutrophil migration was reduced after intra-articular steroid injection. The change in MDP uptake after steroid injection was variable. There was a significant correlation between the percentage reduction in neutrophil migration and pain score, while the latter correlated poorly with the change in MDP uptake. The quantification of the neutrophil component of the inflammatory process is a sensitive index for monitoring RA activity and response to pharmacological interventions, while quantitative bone scintigraphy should not be employed to monitor changes in joint inflammation in patients with RA.

引用

页码：528 / 534

页数：7

共 13 条

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