EFFICACY OF I-131 ABLATION FOLLOWING THYROIDECTOMY IN PATIENTS WITH INVASIVE FOLLICULAR THYROID-CANCER

被引:17
作者
DAVIS, NL [1 ]
GORDON, M [1 ]
GERMANN, E [1 ]
MCGREGOR, GI [1 ]
ROBINS, RE [1 ]
机构
[1] VANCOUVER GEN HOSP,VANCOUVER V5Z 1M9,BC,CANADA
关键词
D O I
10.1016/0002-9610(92)90390-D
中图分类号
R61 [外科手术学];
学科分类号
摘要
The role of thyroid ablation following thyroidectomy for invasive follicular cancer remains controversial. The use of iodine 131 (I-131) ablation as adjuvant therapy may facilitate follow-up of patients in whom serum thyroglobulin levels and I-131 total body scans are used to detect metastatic disease. It is uncertain if I-131 ablation improves survival of patients with follicular thyroid cancer. Thus, the purpose of this study was to determine if survival is enhanced following ablation, with particular reference to those patients with minimally invasive cancer. Between the years 1955 to 1988, 142 patients with invasive thyroid follicular cancer were treated at the British Columbia Cancer Agency, of whom 71 had minimal invasion and no extrathyroidal extension of tumor. In this group of patients, 46 underwent hormone suppression only, 17 had ablation, and 8 had neither. The average follow-up was 9 years and extended beyond 15 years in many patients. Data were entered in a mainframe computer, and Kaplan-Meier survival analysis was used, comparing crude survival, disease-specific survival, and disease-free survival. There was no significant difference between groups. In patients with follicular thyroid cancer and capsular invasion only, I-131 ablation does not improve survival compared with patients treated with thyroid hormone suppression only.
引用
收藏
页码:472 / 475
页数:4
相关论文
共 14 条
[1]   THE MANAGEMENT OF DIFFERENTIATED THYROID-CANCER IN EUROPE IN 1988 - RESULTS OF AN INTERNATIONAL SURVEY [J].
BALDET, L ;
MANDERSCHEID, JC ;
GLINOER, D ;
JAFFIOL, C ;
COSTESEIGNOVERT, B ;
PERCHERON, C .
ACTA ENDOCRINOLOGICA, 1989, 120 (05) :547-558
[2]  
BIERWALTES WH, 1978, SEMIN NUCL MED, V8, P79
[3]   FOLLICULAR THYROID-CANCER TREATED AT THE MAYO-CLINIC, 1946 THROUGH 1970 - INITIAL MANIFESTATIONS, PATHOLOGICAL FINDINGS, THERAPY, AND OUTCOME [J].
BRENNAN, MD ;
BERGSTRALH, EJ ;
VANHEERDEN, JA ;
MCCONAHEY, WM .
MAYO CLINIC PROCEEDINGS, 1991, 66 (01) :11-22
[4]  
CRILE G, 1985, SURG GYNECOL OBSTET, V160, P409
[5]   SURVIVAL DISCRIMINANTS FOR DIFFERENTIATED THYROID-CANCER [J].
CUNNINGHAM, MP ;
DUDA, RB ;
RECANT, W ;
CHMIEL, JS ;
SYLVESTER, J ;
FREMGEN, A .
AMERICAN JOURNAL OF SURGERY, 1990, 160 (04) :344-347
[6]   CLINICAL-PARAMETERS PREDICTIVE OF MALIGNANCY OF THYROID FOLLICULAR NEOPLASMS [J].
DAVIS, NL ;
GORDON, M ;
GERMANN, E ;
ROBINS, RE ;
MCGREGOR, GI .
AMERICAN JOURNAL OF SURGERY, 1991, 161 (05) :567-569
[7]   DEATHS DUE TO DIFFERENTIATED THYROID-CANCER - A 46-YEAR PERSPECTIVE [J].
HARNESS, JK ;
MCLEOD, MK ;
THOMPSON, NW ;
NOBLE, WC ;
BURNEY, RE .
WORLD JOURNAL OF SURGERY, 1988, 12 (05) :623-629
[8]   TREATING DIFFERENTIATED THYROID-CARCINOMA - WHERE DO WE DRAW THE LINE [J].
MAZZAFERRI, EL .
MAYO CLINIC PROCEEDINGS, 1991, 66 (01) :105-111
[9]  
MCHENRY C, 1989, SURGERY, V106, P956
[10]   THYROID-CANCER - A LETHAL ENDOCRINE NEOPLASM [J].
ROBBINS, J ;
MERINO, MJ ;
BOICE, JD ;
RON, E ;
AIN, KB ;
ALEXANDER, HR ;
NORTON, JA ;
REYNOLDS, J .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (02) :133-147