APOPTOSIS IN THYROID-TISSUE FROM PATIENTS WITH HASHIMOTOS-THYROIDITIS

被引：103

作者：

KOTANI, T

ARATAKE, Y

HIRAI, K

FUKAZAWA, Y

SATO, H

OHTAKI, S

机构：

[1] Department of Laboratory Medicine, Miyazaki, 889-16, Kiyotake

[2] Central Laboratory for Clinical Investigation, Miyazaki Medical College, Miyazaki, 889-16, Kiyotake

[3] Kuma Hospital, Kobe, Hyogo

[4] Sapporo City General Hospital, Hokkaido, 001

来源：

AUTOIMMUNITY | 1995年 / 20卷 / 04期

关键词：

APOPTOSIS; THYROCYTE; HASHIMOTOS THYROIDITIS;

D O I：

10.3109/08916939508995700

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

To clarify whether apoptosis of thyroid follicular epithelial cells occurs at the tissue level in autoimmune thyroiditis, 17 specimens of thyroid tissues with Hashimoto's thyroiditis were stained for fragmented DNA. Almost all nuclei of follicular epithelial cells forming atrophic thyroid follicles surrounded by mononuclear cell infiltration and fibrosis showed positive staining. With increasing distance from lymphoid cell follicles, the percentage of follicular epithelial cells with DNA fragmentation-positive nuclei decreased (30-80%). Electron microscopic study revealed the existence of epithelial cells with shrunk and condensed nuclei. The Frequency of those cells in different areas was almost compatible with that of cells with fragmentation-positive nuclei. These findings suggest that apoptosis plays an important role in the thyroid tissue injury in autoimmune thyroiditis.

引用

页码：231 / 236

页数：6

共 12 条

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