THE INTERACTION OF ANHYDROALDITOLS WITH SWEET-ALMOND BETA-GLUCOSIDASE AND ESCHERICHIA-COLI BETA-GALACTOSIDASE - IMPLICATIONS FOR THE DESIGN OF POTENT GLYCOSIDASE INHIBITORS

被引：11

作者：

FIELD, RA

HAINES, AH

CHRYSTAL, EJT

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

[2] ICI PLC,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(01)81044-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A range of 1,4- and 1,5-anhydroalditols have been synthesized and assessed for their ability to inhibit glycosidases. Observed inhibition indicates that aglycone-enzyme interactions contribute significantly to both the affinity and the stereoselectivity of substrate binding. Such interactions may also contribute to enzyme-transition state interactions. Implications for the design of potent glycosidase inhibitors are discussed.

引用

页码：667 / 672

页数：6

共 18 条

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